Hepatitis associated with infantile diarrhoea.

some cases. Others have described changes varying from moderate periportal fatty degeneration to generalized fatty change with cellular necrosis (Blacklock, Guthrie, and Macpherson, 1937; Bray, 1945; Christensen and Biering-Soerensen, 1946; Giles, 1948). In addition to fatty change, Sakula (1943) noted in some cases an 'early proliferation of bile canaliculi as seen in adult cirrhosis' and that 'these changes were most conspicuous in the jaundiced livers'. Most cases of infantile diarrhoea show no pathological evidence of gastro-enteritis, and one is uncertain not only of the basic pathology of the condition, but even whether one is dealing with a single entity or a group of conditions. The number of cases showing acute ulcerative enteritis is small, but the following 15 cases have been collected from 350 consecutive necropsies at the Duchess of York Hospital for Babies, Manchester, and have been divided into two groups, those with jaundice and those without (Table 1). Thus five of 15 cases with an acute ulerative enteritis show a form of hepatitis, and this is more common in the jaundiced cases in which the most severe liver damage might be